1858: Dr. Squibb, American naval doctor, establishes a pharmaceutical laboratory in Brooklyn.

1887: Messieurs Bristol and Myers, two young American graduates, buy a medicines factory in New York State.

1935: In Agen, France, Dr. Camille Bru establishes the UPSA (Union de Pharmacologie Scientifique Appliquée – The Union of Applied Scientific Pharmacology).

1962: The Bristol Benelux laboratories establish in Belgium, the Grand-Duchy of Luxembourg and the Netherlands.

1989: Bristol-Myers and Squibb merge.

1994: Upsa becomes a 100% subsidiary of the Bristol-Myers Squibb Company.

1998: Creation of the “Institut Belge de la Douleur-UPSA-Belgisch Pijninstituut” [Belgian Institute for Pain-UPSA].